NUS Graduate School for Integrative Sciences and Engineering

CHEN Li Hsian Christopher

Research Areas
Brief Description of Research
1. Bioimaging
2. Drug Development
3. Molecular Epidemiology
4. Molecular Medicine
5. Neurobiology


Dr Christopher Chen Li-Hsian is currently an Associate Professor at the Department of Pharmacology and Director of the Memory Aging and Cognition Centre, National University Health System. His major research and clinical interests are in the neurochemistry, molecular biology, imaging and treatment of stroke and dementia. He has published over 300 peer-reviewed papers and book chapters, served on several editorial boards, trial steering committees and data safety monitoring boards. He is currently the Principal Investigator of the CHIMES, NEURITES and ATHENE trials, which have extensive international collaborations. Longitudinal studies are in progress to study the natural history, risk factors of and treatment for the prevention of cognitive impairment and dementia. In addition, he hopes to develop synergies with basic neuroscience research so as to translate novel scientific findings into therapeutic possibilities as well as to provide clinical insights for disease management. Hence he works closely with scientists from A*STAR, NTU, Duke-NUS and NUS to study the mechanisms underlying the pathophysiology of stroke and dementia.

1. Emulation of trials for vascular risk factors in Mild Cognitive Impairment and cognitively normal individuals.
2. Neuroimaging in cognitively normal elderly, Mild Cognitive Impairment and dementia.
3. Statins, cerebrovascular diseases and Dementia.