NUS Graduate School for Integrative Sciences and Engineering

Prabha SAMPATH

RI Supervisor
Research Areas
Brief Description of Research

Prabha Sampath

Prabha SAMPATH
email

Personal Website

1. Cancer Research
2. Cell and Molecular Biology
3. Molecular Medicine
4. Stem Cell Biology & Regenerative Medicine

 

Protein translation is tightly regulated by the sequence and structural elements in the 3’ and 5’ untranslated regions of the transcript and its binding factors. In addition to translation of messenger RNA, non-coding RNAs, both small microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), influence the translation process and its machinery.  Translational control of gene expression defines the proteome and differentially translated genes in a specific pathological condition mirror the spectrum of proteins synthesized. Research in my laboratory is mainly focused on exploring molecular mechanisms of translational regulation/dys-regulation in multiple pathological conditions including cancer and wound healing disorders especially in chronic non-healing wounds. Visualizing these interactions at the molecular level, our objective has been to identify specific novel therapeutic targets.