NUS Graduate School for Integrative Sciences and Engineering

Saji Kumar SREEDHARAN

Supervisor
Research Areas
Brief Description of Research
1. Synaptic Plasticity
2. Long-term Memory
3. Neurodegeneration
4. Sleep Deprivation
5. Epigenetics and Memory

 

The main focus of my research is to understand the fundamental mechanisms of memory, and more specifically how short-term memories are consolidated in a time dependent manner. For investigating the mechanisms of memory, we have mainly adopted activity dependent synaptic plasticity mechanisms such as long-term potentiation (LTP) and long-term depression (LTD) and its associative processes such as synaptic tagging and capture (STC) as models. STC, at cellular level provides a conceptual basis for how short-term memories are transformed to long-term memories within a specific time frame. The major research areas are:

(1) Synaptic mechanisms –defining synaptic mechanisms underlying memory and memory disorders using synaptic tagging /Capture and metaplasticity using rodents and non-human primates (NHP) models.

(2) Molecular mechanisms –defining cellular and molecular mechanisms underlying dementia-related circuit defects.

(3) Circuit analysis –characterizing hippocampal microcircuits using optogenetics in isolated brain tissue of normal and dementia model mice

(4) Behavioral causality - determining whether changes in synaptic mechanism cause long-term plasticity and memory deficits in rodents.