ER Jun Cheng, PhD

Thesis Title: The Evolution of Fluorescent Probe Development

1. Zhang, L.;† Er, J. C.;† Jiang, H.; Li, X.; Luo, Z.; Yi, F.; Thomas, R.; Tang, M. K.; Chang, Y.-T.; Vendrell, M., A Highly Selective Fluorogenic Probe for Cu/Zn Superoxide Dismutase. Chem. Commun. 2016, 52, 9093-9096. († Co-first authorship)
2. Wang, L.; Yuan, L.; Zeng, X.; Peng, J.; Er, J. C.; Xu, W.; Agrawalla, B. K.; Su, D.; Chang, Y.-T., A Multisite-Binding Switchable Fluorescent Probe for Monitoring Mitochondrial ATP Level Fluctuation in Live Cells. Angew. Chem., Int. Ed. 2016, 55 (5), 1773-1776.
3. Teoh, C. L.; Er, J. C.; Mukherjee, P.; Chang, Y.-T., NeuO for Neuronal Labelling in Zebrafish. Tomography 2015, 1 (1), 30-36.
4. Er, J. C.;† Leong, C.;† Teoh, C. L.; Yun, S.-W.; Chang, Y.-T.; et al., NeuO: a Fluorescent Chemical Probe for Live Neuron Labeling. Angew. Chem., Int. Ed. 2015, 54 (8), 2442-2446. († Co-first authorship) (Highlighted in Straits Times, Aug. 17, 2015 and Aug. 21, 2015) (IF: 11.261)
5. Zhang, L.; Er, J. C.; Li, X.; Heng, J. J.; Samanta, A.; Chang, Y.-T.; Lee, C.-L. K., Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach. Chem. Commun. 2015, 51 (34), 7386-7389. († Co-first authorship) (IF: 6.834)
6. Peng, J.; Xu, W.; Teoh, C. L.; Han, S.; Kim, B.; Samanta, A.; Er, J. C.; Wang, L.; Yuan, L.; Liu, X.; Chang, Y.-T., High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles. J. Am. Chem. Soc. 2015, 137 (6), 2336-2342. (IF: 12.113)
7. Zhang, L.; Er, J. C.; Xu, W.; Qin, X.; Samanta, A.; Jana, S.; Lee, C.-L. K.; Chang, Y.-T., “Orange alert”: A fluorescent detector for bisphenol A in water environments. Anal. Chim. Acta 2014, 815 (0), 51-56.
8. Zhang, L.;† Er, J. C.; † Ghosh, K. K.; Chung, W. J.; Yoo, J.; Xu, W.; Zhao, W.; Phan, A. T.; Chang, Y.-T., Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe. Sci. Rep. 2014, 4, 3776. († Co-first authorship)
9. Er, J. C.; Vendrell, M.; Tang, M. K.; Zhai, D.; Chang, Y.-T., Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin. ACS Comb. Sci. 2013, 15 (9), 452-457. (Cover Page in ACS Comb. Sci. 2013, September issue)
10. Er, J. C.; Tang, M. K.; Chia, C. G.; Liew, H.; Vendrell, M.; Chang, Y.-T., MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes. Chem. Sci. 2013, 4 (5), 2168-2176. (IF: 9.211)
11. Xu, W.; Kim, T.-H.; Zhai, D.; Er, J. C.; Zhang, L.; Kale, A. A.; Agrawalla, B. K.; Cho, Y.-K.; Chang, Y.-T., Make caffeine visible: a fluorescent caffeine “Traffic Light” detector. Sci. Rep. 2013, 3, 2255. (Highlighted in ABC News, Aug. 8, 2013 and Real Clear Science, Aug 4, 2013)
12. Vendrell, M.; Zhai, D.; Er, J. C.; Chang, Y.-T., Combinatorial strategies in fluorescent probe development. Chem. Rev. 2012, 112 (8), 4391-4420. (IF: 46.568)

Patents

YIM Guo Rong Daniel, PhD

Thesis Title: The Regulation of Sprouty by Casein Kinase 1

Publications

1. Kaiwen Ivy Liu, Muhammad Nadzim Bin Ramli, Cheok Wei Ariel Woo, Yuanming Wang, Tianyun Zhao, Xiujun Zhang, Guo Rong Daniel Yim, Bao Yi Chong, Ali Gowher, Mervyn Zi Hao Chua, Jonathan Jung, Jia Hui Jane Lee, Meng How Tan (2016). A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing. Nature Chemical Biology A.O.P. 12 September 2016, doi:10.1038/nchembio.2179
2. Jia-Chi Yeo, Jianming Jiang, Zi-Ying Tan, Guo-Rong Yim, Jia-Hui Ng, Jonathan Göke, Petra Kraus, Hong-Qing Liang, Kevin Andrew Uy Gonzales, Han-Chung Chong, Cheng-Peow Tan, Yee-Siang Lim, Nguan-Soon Tan, Thomas Lufkin and Huck-Hui Ng (2014). Klf2 is an essential factor that sustains ground state pluripotency. Cell Stem Cell 14(6), 864–872 (PMID: 24905170)
3. Daniel GR Yim, Sujoy Ghosh, Graeme R Guy and David M Virshup (2014). Casein Kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene Jan 22;34(4):474-84. doi: 10.1038/onc.2013.564. Epub 2014 Jan 27. (PMID: 24469046)
4. Daniel GR Yim and David M Virshup (2013). Unwinding the Wnt action of Casein Kinase 1. Cell Research 23(6), 737-8. Epub 2013 Apr 9 (PMID: 23567556)
5. Yim Guo Rong Daniel (2012). Ethical Theory for "Dual-Use" Dilemmas in Synthetic Biology. Asian Bioethics Review 4.2: 150-159
6. Manjeet Mukherjee, Soah Yee Chow, Permeen Yusoff, J Seetharaman, Cherlyn Ng, Saravanan Sinniah, Xiao Woon Koh, Nur Farehan M Asgar, Dan Li, Daniel Yim, Rebecca A Jackson, Jingxi Yew, Jingru Qian, Audrey Iyu, Yoon Pin Lim, Xingding Zhou, Siu Kwan Sze, Graeme R Guy and J Sivaraman (2012). Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. The EMBO Journal 31, 1308 - 1319 (PMID: 22252131)
7. G.R. Yim, D.R. Ding, C.P. Wang, W.H. Leong and Y. Hong (2009). Microsatellite Markers to Complement Distinctness, Uniformity, Stability Testing of Brassica chinensis (Xiao Baicai) Varieties. The Open Horticulture Journal 2: 54-61 (ISSN: 1874-8406)

LAI Chow Yin, PhD

Thesis Title: Identification and Control of Nonlinear Systems using Multiple Models

Patent

1. 2014: W. K. Teo, P. Y. Tao, C. Y. Lai, T. M. Lim, and S. Subbiah, “A Deterministic Model-Based Material Removal Method for Fan Blade Leading Edge Re-Profiling”, submitted for United States and European Union patent application.

Book Chapter

1. C. Y. Lai and Y. C. Sun (2014). Robotic Finishing. In  A. Y. C. Nee (Ed.), Handbook of Manufacturing Engineering and Technology, Volume Robotics and Automation, Springer, November 2014.

Journals

1. C. Y. Lai, C. Xiang, and T. H. Lee, “Data-based Identification and Control of Nonlinear Systems via Piecewise Affine Approximation,” IEEE Trans. Neural Networks, Vo. 22, No. 12, 2011, pp. 2189-2200.
2. C. Y. Lai, C. Xiang, and T. H. Lee, “Input-output Transition Models for Discrete-time Switched Linear and Nonlinear Systems,” Control and Intelligent Systems, Vol.39, No. 1, 2011, pp. 47-59.
3. C. Y. Lai, F. L. Lewis, V. Venkataramanan, X. Ren, S. S. Ge and T. Liew, “Disturbance and Friction Compensation in Hard Disk Drives using Neural Networks,” IEEE Trans. Industrial Electronics, Vol. 57, No. 2, 2010, pp. 784-792.
4.  X. Ren, C. Y. Lai, V. Venkataramanan, F. L. Lewis, S. S. Ge and T. Liew, “Feedforward Control Based on Neural Networks for Disturbance Rejection in Hard Disk Drives,” IET Control Theory and Applications, Vol. 3, Issue 4, 2009, pp. 411-418.

Conference Proceedings

1. T. Y. Wu and C. Y. Lai, “An Adaptive Neural Network Compensator for Decoupling of Dynamic Effect in a Macro-Mini Manipulator,” accepted for presentation at the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, July 2015, Busan, Korea.
2. J. S. Short, A. N. Poo, M. H. Ang, C. Y. Lai, and P. Y. Tao, “A Generalized Underactuated Robot System Inversion Method using Hamiltonian Formalism,” accepted for presentation at the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, July 2015, Busan, Korea.
3. C. Y. Lai, “Improving Transient Performance in Robotics Force Control using Nonlinear Damping,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 892-897.
4. C. Y. Lai, “Decoupling of Macro-Mini Manipulator using Adaptive Neural Networks,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 898-903.
5. J. S. Short, A. N. Poo, M. H. Ang, C. Y. Lai and P. Y. Tao, “Hamiltonian Exploitation in Underactuated Robot System Inversion”, in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Besancon, France, July 2014, pp. 904-909.
6. A. S. Arifin, M. H. Ang, C. Y. Lai, and C. W. Lim, “General Framework of the Force and Compliant Motion Control for Macro Mini Manipulator,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Wollongong, Australia, Jul 2013, pp. 949-954.
7. A. S. Arifin, M. H. Ang, C. W. Lim, and C. Y. Lai, “Improving Positioning Accuracy using a General Framework for Macro Mini Manipulation,” in Proceedings of the IFAC Symposium on Mechatronic Systems, Hangzhou, China, Apr 2013, pp. 225-230.
8. C. Y. Lai, Y. P. Li, N. D. Vuong, T. M. Lim, C. Y. Ma, and C. W. Lim, “Nonlinear Damping for Improved Transient Performance in Robotics Force Control,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Kaohsiung, Taiwan, Jul. 2012, pp. 314-319.
9. P. Y. Tao, G. Yang, Y. C. Sun, M. Tomizuka, and C. Y. Lai, “Product-of-Exponential (POE) Model for Kinematic Calibration of Robots with Joint Compliance,” in Proceedings of the IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Kaohsiung, Taiwan, Jul. 2012, pp. 496-501.
10.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Nonlinear Systems using Piecewise Affine Models,” in Proceedings of the 11th International Conference on Control, Automation, Robotics and Vision, Singapore, December 2010, pp. 2259-2265.
11.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Nonlinear Systems via Piecewise Affine Approximation,” in Proceedings of the IEEE Conference on Decision and Control, Atlanta, USA, December 2010, pp. 6395-6402.
12.  C. Y. Lai, C. Xiang, and T. H. Lee, “Identification and Control of Piecewise Affine Systems using Multiple Models and Model Predictive Control,” in Proceedings of the 12th IASTED International Conference on Control and Applications 2010, Banff, Canada, July 2010, pp. 530-537.
13. C. Y. Lai, C. Xiang, and T. H. Lee, “Identification of Piecewise Affine Systems and Nonlinear Systems using Multiple Models,” in Proceedings of the IEEE International Conference on Control and Automation 2010, Xiamen, China, June 2010, pp. 2005-2012.
14. C. Y. Lai, C. Xiang, and T. H. Lee, “Identification of Linear Time-Varying System using Multiple Models,” in Proceedings of the IASTED International Conference on Modelling, Simulation and Identification (Robotics, Telematics and Applications), Beijing, China, Oct. 2009, paper 661-028.
15. C. Xiang, C. Y. Lai, T. H. Lee, and K. S. Narendra , “A General Framework for Least-Squares Based Identification of Time-Varying System using Multiple Models,” in Proceedings of the IEEE International Conference on Control and Automation 2009, Christchurch, New Zealand, Dec. 2009, pp. 212-219.
16. C. Y. Lai, C. Xiang, and T. H. Lee “Input-output Transition Models for Discrete-time Switched Nonlinear Systems,” in Proceedings of the 2009 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Singapore, July 2009, pp. 112-117.
17. C. Y. Lai, F. L. Lewis, V. Venkataramanan, X. Ren, S. S. Ge and T. Liew, “Neural Networks for Disturbance and Friction Compensation in Hard Disk Drives“, in Proceedings of the 47th IEEE Conference on Decision and Control, Cancun, Mexico, 2008, pp. 3640-3645.

CHEN Zhi Xiong, PhD

Thesis Title: Role of Bcl-2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells

Selected Peer-reviewed Publications

1. Cai, W.*, Chen, Z.X.*, Rane, G., Singh, S.S., Choo, Z., Wang, C., Yuan, Y., Tan, T.Z., Arfuso, F., Yap, C.T., Pongo, L.S., Yang, H., Lee, M.B., Goh, B.C., Sethi, G., Benoukraf, T., Tergaonkar, V., Kumar, A.P. Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. J Natl Cancer Inst (2017) 109 (6): djw278. doi: https://doi.org/10.1093/jnci/djw278
2. Choo, Z., Koh, R.Y., Wallis, K., Koh, T.J., Kuick, C.H., Sobrado, V., Kenchappa, R.S., Loh, A.H., Soh, S.Y., Schlisio, S., Chang, K.T. and Chen, Z.X. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget. 7(23):34229-39, 7 Jun 2016
3. Li, S., Fell, S.M., Surova, O., Smedler, E., Wallis, K., Chen, Z.X., Hellman, U., Johnsen, J.I., Martinsson, T., Kenchappa, R.S., Uhlén, P., Kogner, P., and Schlisio, S. The 1p36 tumor suppressor KIF1Bβ is required for Calcineurin activation controlling mitochondrial fission and apoptosis.  Developmental Cell, Volume 36, Issue 2, p164–178, 25 January 2016 
4. Chen, Z.X., Wallis, K., Fell, S.M., Sobrado, V.R., Hemmer, M.C., Ramsköld, D., Hellman, U., Sandberg, R., Kenchappa, R., Martinsson, T., Johnsen, J.I., Kogner, P. and Schlisio, S. RNA helicase A is a downstream mediator of KIF1Bβ tumor suppressor function in neuroblastoma. Cancer Discov. 4(4):434-51, 20 Mar 2014*
   *Bernards, R. Unlikely suspects identified in neuroblastoma conspiracy. Cancer Discov. 4(4):392-3, 4 Apr 2014. (Article Highlight)

Farhana Binte Mohmammed Anuar, PhD

Thesis Title: The role of nitric oxide and other gaseous mediators in cardiovascular disease models; emphasis on septic shock